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T23861 |
CAY10526
|
CAY-10526,BTH,CAY 10526 |
Prostaglandin Receptor
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CAY10526 (BTH) is a selective mPGES-1 inhibitor that acts as an inhibitor of the NF-κB signaling pathway. |
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T11209 |
EOAI3402143
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DUB
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EOAI3402143 inhibits Usp9x and Usp24 activity, increases tumor cell apoptosis. EOAI3402143 phenocopies the FAS induction and apoptotic sensitization of Usp5 knockdown and fully blocks melanoma tumor growth. |
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T15469 |
Hematein
|
Hydroxybrasilein |
Wnt/beta-catenin
,
Akt
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|
Hematein inhibits Akt/PKB Ser129 phosphorylation, the Wnt/TCF pathway, and increases apoptosis in lung cancer cells. Hematein is an oxidation product of hematoxylin acted as a dye and it also is an allosteric casein kina... |
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T22094 |
JGB1741
|
ILS-JGB-1741 |
Sirtuin
|
|
JGB1741 (ILS-JGB-1741) is a potent and selective inhibitor of SIRT1 with an IC50 of 15 μM. JGB1741 modulates Bax/Bcl2 ratio, cytochrome c release and PARP cleavage and increases the acetylated p53 levels leading to p53-m... |
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T83653 |
SACLAC
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|
Apoptosis
,
Caspase
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SACLAC is a cysteine asparaginase activation inhibitor with antitumor activity that decreases AML cell viability, inhibits AML cell proliferation, increases AML cell death, and induces apoptosis of AML cells, and is used... |
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T14021 |
20-HETE
|
20-hydroxy Arachidonic Acid |
Others
|
|
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH ... |
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T63992 |
KS100
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|
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KS100 is a potent inhibitor of ALDH, acting on ALDH1A1 (IC50: 334 nM), ALDH2 (IC50: 2137 nM) and ALDH3A1 (IC50: 360 nM). KS100 significantly increases ROS activity, lipid peroxidation and the accumulation of toxic aldehy... |
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T68170 |
Xl-281
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|
|
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XL-281 is a potent, selective, orally active inhibitor of wild-type and mutant RAF kinases with anti-tumor activity in multiple xenograft models; demonstrates biological activity by modulation of the RAF pathway in tumor... |
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T38034 |
MAO-IN-M30 dihydrochloride
|
M 30 dihydrochloride |
Monoamine Oxidase
|
|
MAO-IN-M30 dihydrochloride (M 30 dihydrochloride) is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant... |
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T38294 |
4-Deoxypyridoxine hydrochloride
|
|
S1P Receptor
|
|
4-Deoxypyridoxine (4-DPD) is a vitamin B6 antimetabolite with diverse biological activities. It inhibits transport of pyridoxine , pyridoxal, and pyridoxamine in and reduces growth of S. carlsbergensis cells. 4-DPD inhib... |
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T35689 |
MTP 131 acetate
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|
Others
|
|
MTP 131 is a mitochondria-targeted peptide antioxidant.1,2It localizes to the mitochondria and reducestert-butyl hydroperoxide-induced lipid peroxidation and apoptosis in SH-SY5Y cells when used at concentrations ranging... |
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T35610 |
2,5-dimethyl Celecoxib
|
|
Apoptosis
,
Wnt/beta-catenin
,
Prostaglandin Receptor
|
|
2,5-dimethyl Celecoxib is a derivative of celecoxib that does not inhibit COX-2 (IC50 = >100 μM).1 It does inhibit microsomal prostaglandin E synthase-1 (mPGES-1) in HeLa cells (IC50 = 15.6 μM) and reduces prostaglandin ... |
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T36083 |
DS-7423
|
|
PI3K
,
mTOR
|
|
DS-7423 is a dual PI3K and mTOR inhibitor, with IC50 values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity[1][2].
DS-7423 increases TP53 expression, the level of p-TP53 on Ser... |
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T28027 |
Methotrexate monohydrate
|
Methotrexate hydrate |
|
|
Methotrexate monohydrate is a DHhF reductase inhibitor. Methotrexate monohydrate increases T cell apoptosis, decreases T cell activation and suppresses cytokine production. |
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T71830 |
DT204
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|
|
|
DT204 is a SCFSkp2 inhibitor which blocks Skp2 binding to Cullin-1 and Commd1, thereby synergistically enhancing BTZ-induced apoptosis and stabilization. DT204 also increases p27 levels. |
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T32419 |
KRAS4b-PDEδ stabilizer C19
|
|
|
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KRAS4b-PDEδ stabilizer C19 is a stabilizer of the KRAS4b-PDEδ complex which decreases the proliferation of colorectal cancer cells, and increases apoptosis via decreased activation of oncogenic KRAS4b signaling. |
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T36944 |
Ara-G
|
|
Nucleoside Antimetabolite/Analog
|
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Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine .1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporate... |
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T69429 |
Y27632 HCl hydrate
|
|
|
|
Y27632 is a selective ROCK inhibitor, which inhibits ET-1-induced increases in natriuretic peptide production, cell size, protein synthesis, and myofibrillar organization. Y27632 prevents dimethylnitrosamine-induced hepa... |
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T63917 |
Anticancer agent 67
|
|
|
|
Anticancer agent 67 is a ciprofloxacin analogue, an anticancer agent that induces apoptosis and increases sub-G1 cell populations in MCF-7 cells. |
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TP2296 |
TLQP-21
|
|
Others
|
|
TLQP 21 is a VGF-derived peptide. TLQP 21 can protect cerebellar granule cells (CGCs) from serum and potassium deprivation-induced apoptosis and increases energy expenditure and prevents early phase diet-induced diabetes... |
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T63477 |
PI3Kα-IN-8
|
|
|
|
PI3Kα-IN-8 is a selective inhibitor of PI3Kα (IC50: 0.012 μM). PI3Kα-IN-8 increases intracellular levels of reactive oxygen species, decreases mitochondrial membrane potential, and induces apoptosis. |
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T62073 |
PI3Kα-IN-6
|
|
|
|
PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor that exhibits anticancer effects without toxicity to normal cells. PI3Kα-IN-6 increases ROS production, decreases mitochondrial membrane potential and induces apoptosis. |
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T36507 |
Tetrachlorohydroquinone
|
|
|
|
Tetrachlorohydroquinone (TCHQ) is a metabolite of the organochlorine biocide pentachlorophenol. It is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay). TCHQ increases production of re... |
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T36610 |
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine
|
|
|
|
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP r... |
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T36073 |
S-Acetyl-L-glutathione
|
|
|
|
S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 μM. S-... |
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T75823 |
GLP-2(rat) TFA
|
|
|
|
GLP-2(rat) TFA, an intestinal growth factor, promotes cell proliferation and prevents apoptosis. Additionally, it increases mucosal mass and function in the residual small intestine following massive small bowel resectio... |
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T63452 |
Benidipine
|
|
|
|
Benidipine is a potent, orally active calcium channel antagonist. benidipine increases endothelial nitric oxide synthase activity and improves coronary circulation in hypertensive rats. benidipine resists apoptosis in is... |
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T36221 |
2-chloro Palmitic Acid
|
|
|
|
2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic aci... |
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T79482 |
Anticancer agent 137
|
|
PI3K
|
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Anticancer agent 137 (8q), a potent PI3k inhibitor, exhibits broad-spectrum anticancer activity by inducing G2/M cell cycle arrest and apoptosis. It increases levels of cleaved PARP, and caspases 3 and 7, making it usefu... |
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T15670 |
KT5823
|
|
Apoptosis
,
PKA
|
|
KT5823 is a selective and potent cGMP-dependent protein kinase (PKG) inhibitor with inhibitory effects on PKA and PKC.KT5823 increases thyroid-stimulating hormone-induced (Na+/I- symporter) NIS expression and iodide ion ... |
|
T36321 |
C6 Urea Ceramide
|
|
|
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C6 urea ceramide is an inhibitor of neutral ceramidase.1 It increases total ceramide levels in wild-type mouse embryonic fibroblasts (MEFs) and in HT-29 colon cancer cells but not in MEFs lacking neutral ceramidase. It i... |
|
T76252L |
WLSEAGPVVTVRALRGTGSW TFA
|
|
|
|
WLSEAGPVVTVRALRGTGSW TFA, a cardiomyocyte-specific peptide, exhibits enhanced performance through its expression in exosomes, which notably improves uptake by cardiomyocytes, reduces apoptosis within these cells, and inc... |
|
T63179 |
BTK-IN-9
|
|
|
|
BTK-IN-9 is a reversible inhibitor of BTK that shows strong anti-proliferative effects in condyloma cells.BTK-IN-9 specifically disrupts mitochondrial membrane potential, increases reactive oxygen species levels in Z138 ... |
|
T36098 |
Isovaleryl-L-carnitine (chloride)
|
|
|
|
Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocyt... |
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T64022 |
Antitumor agent-37
|
|
|
|
Antitumor agent-37 exhibits potent anti-proliferative and anti-metastatic effects. antitumor agent-37 induces severe DNA damage, leading to high expression of γ-H2AX and p53. antitumor agent-37 induces apoptosis by explo... |
|
T36099 |
Jacaric Acid
|
|
|
|
Jacaric acid is a conjugated polyunsaturated fatty acid first isolated from seeds of Jacaranda plants. Structurally, it is an 18-carbon ω-6 triene isomer of γ-linolenic acid . Jacaric acid induces cell cycle arrest and a... |
|
T62111 |
Antioxidant agent-5
|
|
|
|
Antioxidant agent-5 (compound D-6) is a potent antioxidant. antioxidant agent-5 inhibits oxLDL-induced increases in ROS levels and NF-κB nuclear translocation. antioxidant agent-5 inhibits oxLDL (oxidized LDL)-induced ap... |
|
T71285 |
Metaxalone-d6
|
|
|
|
Metaxalone-d6 is intended for use as an internal standard for the quantification of metaxalone by GC-or LC-MS. Metaxalone is a skeletal muscle relaxant. It inhibits the proliferation of, and induces apoptosis in, RAW 264... |
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T63879 |
MicroRNA-21-IN-1
|
|
|
|
MicroRNA-21-IN-1 (compound 7A) is an effective inhibitor of microRNA with antiproliferative effects on Hela and HCT-116 cells, showing IC50 values of 5.5 μM and 2.8 μM, respectively. It also induces apoptosis in Hela cel... |
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T63494 |
Antitumor agent-60
|
|
|
|
Antitumor agent-60 is a potent antitumor agent that targets the RAS-RAF signaling pathway and binds to CRAF (Kd: 721.3 nM). antitumor agent-60 increases p53 and ROS levels in cancer cells, resulting in oval and irregular... |
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T38389 |
Prostaglandin D2 Ethanolamide
|
Prostaglandin D2 Ethanolamide |
|
|
Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The ... |
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T37469 |
Sitamaquine tosylate
|
|
|
|
Sitamaquine is an antileishmanial agent.1It is active againstL. donovani,L. infantum,L. mexicana,L. braziliensis, andL. tropica(EC50s = 9.5-19.8 μM). It inhibits mitochondrial complex II, also known as succinate dehydrog... |
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T35622 |
FKGK 18
|
|
|
|
FKGK 18 is an inhibitor of group VIA (GVIA) calcium-independent phospholipase A2 (iPLA2). It inhibits GVIA iPLA2 by 99.9% at 0.091 mole fraction in a mixed micelle activity assay and is selective for GVIA iPLA2 over GIVA... |
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T79274 |
PRMT5-IN-31
|
|
Histone Methyltransferase
|
|
PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 and establishing key interactions with amino acid residues. It exhibits a... |
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T60453 |
TrxR-IN-3
|
|
|
|
TrxR-IN-3 (Compound 2c) is a effective TrxR inhibitor. TrxR-IN-3 shows strong antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and l... |
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T36882 |
CAY10773
|
|
|
|
CAY10773 is a derivative of the ferroptosis inducer sorafenib .1It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells (IC50s = 5.77, 5.21 and 3.97 μM, respectively) over non-cancerous HC... |
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T35778 |
Ochratoxin A-13C20
|
Ochratoxin A-13C20 |
|
|
Ochratoxin A-13C20is intended for use as an internal standard for the quantification of ochratoxin A by GC- or LC-MS. Ochratoxin A is a mycotoxin that has been found inAspergillusandPenicillium.1It increases lipid peroxi... |
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T35552 |
Ganglioside GD3 Mixture (sodium salt)
|
|
|
|
Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases.... |
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T36194 |
CAY10726
|
CAY10726 |
|
|
CAY10726 is an arylurea fatty acid. It decreases ATP production by 28% in MDA-MB-231 breast cancer cells when used at a concentration of 10 μM. CAY10726 decreases proliferation and initiates apoptosis in MDA-MB-231 cells... |
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T35762 |
MC1742
|
|
|
|
MC1742 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 0.1, 0.11, 0.02, and 0.61 μM for HDAC1, -2, -3, and -8, respectively) and class IIb HDACs (IC50s = 7 and 40 nM for HDAC6 and HDAC10, respectively).1 ... |
